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Article

MYC association with cancer risk and a new model of MYC-mediated repression.

Cold Spring Harbor perspectives in medicine - 1 Jul 2014

Cole Michael D

Abstract excerpt

MYC is one of the most frequently mutated and overexpressed genes in human cancer but the regulation of MYC expression and the ability of MYC protein to repress cellular genes (including itself) have remained mysterious. Recent genome-wide association studies show that many genetic polymorphisms associated with disease risk map to distal regulatory elements that regulate the MYC promoter through large chromatin...

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Topics

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Share to DNA Methylation
Share to Enhancer of Zeste Homolog 2 Protein
Share to Genes, myc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phosphorylation

Share to Polycomb Repressive Complex 2

Share to Proto-Oncogene Proteins c-myc

Share to PTEN Phosphohydrolase

Source

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Identifiers

PMID: 24985129
DOI: 10.1101/cshperspect.a014316
PMCID: PMC4066640

Genes

MYC
PTEN

Provenance

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