Multiple loci with different cancer specificities within the 8q24 gene desert.

doi:10.1093/jnci/djn190

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Article

Multiple loci with different cancer specificities within the 8q24 gene desert.

Journal of the National Cancer Institute - 2 Jul 2008

Ghoussaini Maya, Song Honglin, Koessler Thibaud, Al Olama Ali Amin, Kote-Jarai Zsofia, Driver Kristy E, Pooley Karen A, Ramus Susan J, Kjaer Susanne Krüger, Hogdall Estrid, DiCioccio Richard A, Whittemore Alice S, Gayther Simon A, Giles Graham G, Guy Michelle, Edwards Stephen M, Morrison Jonathan, Donovan Jenny L, Hamdy Freddie C, Dearnaley David P, Ardern-Jones Audrey T, Hall Amanda L, O'Brien Lynne T, Gehr-Swain Beatrice N, Wilkinson Rosemary A, Brown Paul M, Hopper John L, Neal David E, Pharoah Paul D P, Ponder Bruce A J, Eeles Rosalind A, Easton Douglas F, Dunning Alison M

Abstract excerpt

Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with susceptibility to breast, prostate, and colorectal cancer. This locus lies within a 1.18-Mb region that contains no known genes but is bounded at its centromeric end by FAM84B and at its telomeric end by c-MYC, two candidate cancer susceptibility genes. To...

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PMID: 18577746
DOI: 10.1093/jnci/djn190
PMCID: PMC2902819

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