Article
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Science signaling - 19 Jul 2011
Sundaresan Nagalingam R, Pillai Vinodkumar B, Wolfgeher Don, Samant Sadhana, Vasudevan Prabhakaran, Parekh Vishwas, Raghuraman Hariharasundaram, Cunningham John M, Gupta Madhu, Gupta Mahesh P
Abstract excerpt
Signaling through the kinase Akt regulates many biological functions. Akt is activated during growth factor stimulation through a process that requires binding of Akt to phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1). We show that Akt and PDK1 are acetylated at lysine...
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