Article
SUMOylation regulates AKT1 activity.
Oncogene - 12 Mar 2015
de la Cruz-Herrera C F, Campagna M, Lang V, del Carmen González-Santamaría J, Marcos-Villar L, Rodríguez M S, Vidal A, Collado M, Rivas C
Abstract excerpt
Serine threonine kinase AKT has a central role in the cell, controlling survival, proliferation, metabolism and angiogenesis. Deregulation of its activity underlies a wide range of pathological situations, including cancer. Here we show that AKT is post-translationally modified by the small ubiquitin-like modifier (SUMO) protein. Interestingly, neither SUMO conjugation nor activation of SUMOylated AKT is...
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