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Article

Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling.

Science advances - 1 Aug 2017

Fischer Adrian, Mühlhäuser Wignand W D, Warscheid Bettina, Radziwill Gerald

Abstract excerpt

Spatiotemporal control is a common mechanism that modulates activity and function of signal transducers in the signaling network. We identified acetylation of CNK1 (connector enhancer of kinase suppressor of Ras-1) as a late step in the activation of CNK1 signaling, accompanied with prolonged stimulation of extracellular signal-regulated kinase (ERK). We identified the acetyltransferase CREB (cyclic adenosine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

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Source

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Identifiers

PMID: 28819643
DOI: 10.1126/sciadv.1700475
PMCID: PMC5553820

Genes

SIRT2

Provenance

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