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Article

The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors.

The Journal of biological chemistry - 25 Sept 2009

Meima Marcel E, Webb Bradley A, Witkowska H Ewa, Barber Diane L

Abstract excerpt

The kinase Akt mediates signals from growth factor receptors for increased cell proliferation, survival, and migration, which contribute to the positive effects of Akt in cancer progression. Substrates are generally inhibited when phosphorylated by Akt; however, we show phosphorylation of the plasma membrane sodium-hydrogen exchanger NHE1 by Akt increases exchanger activity (H(+) efflux). Our data fulfill...

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Identifiers

PMID: 19622752
DOI: 10.1074/jbc.M109.019448
PMCID: PMC2785354

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