Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PHLPPing it off: phosphatases get in the Akt.

Molecular cell - 23 Mar 2007

Mendoza Michelle C, Blenis John

Abstract excerpt

Three Akt isoforms differentially control cell survival, growth, proliferation, metabolism, and motility. In this issue of Molecular Cell, Brognard et al. (2007) report that two PHLPP phosphatases specifically downregulate the Akts to control the activity of isoform-specific substrates.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Enzyme Activation
Share to Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Protein Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Substrate Specificity

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 17386258
DOI: 10.1016/j.molcel.2007.03.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PHLPPing it off: phosphatases get in the Akt.PMID 17386258Read ↗

The Akt pathway in oncology therapy and beyond (Review)Semantic proximity Read ↗

AKT isoform-specific expression and activation across cancer lineages.Semantic proximity Read ↗

AKT in cancer: new molecular insights and advances in drug developmentSemantic proximity Read ↗

Akt: a key transducer in cancerSemantic proximity Read ↗

Expression, activation, and role of AKT isoforms in the uterusSemantic proximity Read ↗

Suppression of survival signalling pathways by the phosphatase PHLPP.Semantic proximity Read ↗

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway InhibitorsSemantic proximity Read ↗

Protein phosphatase 1 in tumorigenesis: is it worth a closer look?Semantic proximity Read ↗

Phosphorylation-Dependent Inhibition of Akt1Semantic proximity Read ↗

Live-cell NanoBRET assay to measure AKT inhibitor binding to conformational states of AKTSemantic proximity Read ↗

Perturbations of the AKT signaling pathway in human cancer.Semantic proximity Read ↗

Emerging Roles for AKT Isoform Preference in Cancer Progression PathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.