Article
Pathways and intermediates in forced unfolding of spectrin repeats.
Structure (London, England : 1993) - 1 Aug 2002
Altmann Stephan M, Grünberg Raik G, Lenne Pierre-François, Ylänne Jari, Raae Arnt, Herbert Kristina, Saraste Matti, Nilges Michael, Hörber J K Heinrich
Abstract excerpt
Spectrin repeats are triple-helical coiled-coil domains found in many proteins that are regularly subjected to mechanical stress. We used atomic force microscopy technique and steered molecular dynamics simulations to study the behavior of a wild-type spectrin repeat and two mutants. The experiments indicate that spectrin repeats can form stable unfolding intermediates when subjected to external forces. In the...
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