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Article

Polymorphism of the tryptophan hydroxylase 2 (TPH2) gene is associated with chimpanzee neuroticism.

PloS one - 1 Jan 2011

Hong Kyung-Won, Weiss Alexander, Morimura Naruki, Udono Toshifumi, Hayasaka Ikuo, Humle Tatyana, Murayama Yuichi, Ito Shin'ichi, Inoue-Murayama Miho

Abstract excerpt

In the brain, serotonin production is controlled by tryptophan hydroxylase 2 (TPH2), a genotype. Previous studies found that mutations on the TPH2 locus in humans were associated with depression and studies of mice and studies of rhesus macaques have shown that the TPH2 locus was involved with aggressive behavior. We previously reported a functional single nucleotide polymorphism (SNP) in the form of an amino...

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Identifiers

PMID: 21765945
DOI: 10.1371/journal.pone.0022144
PMCID: PMC3135609

Genes

TPH2

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