Nice guys: Homozygocity for the TPH2 -703G/T (rs4570625) minor allele promotes low aggressiveness and low anxiety.

doi:10.1016/j.jad.2017.03.045

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Article

Nice guys: Homozygocity for the TPH2 -703G/T (rs4570625) minor allele promotes low aggressiveness and low anxiety.

Journal of affective disorders - 1 Jun 2017

Laas Kariina, Kiive Evelyn, Mäestu Jarek, Vaht Mariliis, Veidebaum Toomas, Harro Jaanus

Abstract excerpt

BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of serotonin. We examined whether the TPH2 polymorphism -703G/T (rs4570625) is associated with aggressiveness and impulsivity, and the prevalence of psychiatric disorders, in a population-representative sample. METHODS: We used self and proxy reports on aggressive behaviour in the younger birth cohort of the longitudinal...

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PMID: 28342337
DOI: 10.1016/j.jad.2017.03.045

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TPH2

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