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Article

A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats.

Neuroscience letters - 2 Feb 2007

Hong Kyung-Won, Sugawara Yuko, Hasegawa Hiroyuki, Hayasaka Ikuo, Hashimoto Ryota, Ito Shin'ichi, Inoue-Murayama Miho

Abstract excerpt

Tryptophan hydroxylase 2 (TPH2) is a rate-limiting enzyme of neuronal serotonin biosynthesis. Recently, two single nucleotide polymorphisms (SNPs) at the exon 11 coding region that resulted in amino acid substitutions in the C-terminal domain have been reported to affect enzyme activity in humans...

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Source

Identifiers

PMID: 17123720
DOI: 10.1016/j.neulet.2006.11.010

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17123720-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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