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Article

Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2005

Reuter M, Hennig J

Abstract excerpt

Recent studies from molecular genetics have suggested an association between the tryptophan hydroxylase 1 (TPH1) gene and nicotine addiction indicating a dysfunction of the serotonergic (5-HT) system in smoking behavior. In a sample of 252 healthy subjects, a significant association between varia...

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Source

Identifiers

PMID: 15635702
DOI: 10.1002/ajmg.b.30153

Genes

TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15635702-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality.PMID 15635702Read ↗

Association of anger-related traits with SNPs in the TPH gene.Semantic proximity Read ↗

Polymorphism of the tryptophan hydroxylase 2 (TPH2) gene is associated with chimpanzee neuroticism.Semantic proximity Read ↗

The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts.Semantic proximity Read ↗

Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism.Semantic proximity Read ↗

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.Semantic proximity Read ↗

Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene.Semantic proximity Read ↗

Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains.Semantic proximity Read ↗

Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits.Semantic proximity Read ↗

Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study.Semantic proximity Read ↗

The association between the serotonin and dopamine neurotransmitters and personality traits.Semantic proximity Read ↗

Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits.Semantic proximity Read ↗

A dimensional impulsive-aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: a pilot study in well-characterized impulsive inpatients.Semantic proximity Read ↗

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