Article
The composition of the F pocket in HLA-A*74 generates C-terminal promiscuity among its bound peptides.
Tissue antigens - 1 Nov 2011
Bade-Doeding C, Huyton T, Eiz-Vesper B, Blasczyk R
Abstract excerpt
In this study we sequenced the bound peptides from three alleles belonging to the HLA-A*74 group (HLA-A*74:04, A*74:06 and A*74:07) that are distinguished by four polymorphic residues within the peptide-binding region. Our data illustrates that A*74:04 exhibits preference for L, M or I at P2 and L, S or P at PΩ, while for A*74:07 the P2 anchor prefers L, P or I and the PΩ anchor S, P, L. In contrast A*74:06...
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