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Article

HLA class II peptide-binding-region analysis reveals funneling of polymorphism in action.

Immunology letters - 1 Oct 2021

Sarri Constantina A, Giannoulis Themistoklis, Moutou Katerina A, Mamuris Zissis

Abstract excerpt

BACKGROUND: HLA-class II proteins hold important roles in key physiological processes. The purpose of this study was to compile all class II alleles reported in human population and investigate patterns in pocket variants and their combinations, focusing on the peptide-binding region (PBR). METHODS: For this purpose, all protein sequences of DPA1, DQA1, DPB1, DQB1 and DRB1 were selected and filtered, in order to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34329645
DOI: 10.1016/j.imlet.2021.07.005

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