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Article

Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil.

The Journal of biological chemistry - 6 Feb 2009

Champagne Kelly, Shishido Akira, Root Michael J

Abstract excerpt

Cellular entry of human immunodeficiency virus type 1 (HIV-1) involves fusion of viral and cellular membranes and is mediated by structural transitions in viral glycoprotein gp41. The antiviral C-peptide T20 targets the gp41 N-terminal heptad repeat region (N-HR), blocking gp41 conformational changes essential for the entry process. To probe the T20 structure-activity relationship, we engineered a molecular mimic...

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Drug Resistance, Viral
Enfuvirtide
HeLa Cells
HIV Envelope Protein gp41
HIV Fusion Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Fragments

Protein Structure, Secondary

Virus Internalization

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Identifiers

PMID: 19073602
DOI: 10.1074/jbc.M809269200
PMCID: PMC2635040

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