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Article

Protein Design of an HIV-1 Entry Inhibitor

2 Feb 2001

Abstract excerpt

Human immunodeficiency virus type-1 (HIV-1) membrane fusion is promoted by the formation of a trimer-of-hairpins structure that brings the amino- and carboxyl-terminal regions of the gp41 envelope glycoprotein ectodomain into close proximity. Peptides derived from the carboxyl-terminal region (called C-peptides) potently inhibit HIV-1 entry by binding to the gp41 amino-terminal region. To test the converse of...

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Identifiers

PMID: 11229405
DOI: 10.1126/science.1057453

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