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Article

Trimeric, coiled-coil extension on peptide fusion inhibitor of HIV-1 influences selection of resistance pathways.

The Journal of biological chemistry - 9 Mar 2012

Zhuang Min, Wang Wei, De Feo Christopher J, Vassell Russell, Weiss Carol D

Abstract excerpt

Peptides corresponding to N- and C-terminal heptad repeat regions (HR1 and HR2, respectively) of viral fusion proteins can block infection of viruses in a dominant negative manner by interfering with refolding of the viral HR1 and HR2 to form a six-helix bundle (6HB) that drives fusion between viral and host cell membranes. The 6HB of the HIV gp41 (endogenous bundle) consists of an HR1 coiled-coil trimer with...

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Share to Drug Design
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp41

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Share to Protein Structure, Secondary

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Source

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Identifiers

PMID: 22235115
DOI: 10.1074/jbc.M111.324483
PMCID: PMC3318747

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