Article
Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.
The EMBO journal - 1 Dec 1990
Lee C Q, Yun Y D, Hoeffler J P, Habener J F
Abstract excerpt
Cyclic AMP-regulated gene expression is mediated by specific phosphoproteins (CREBs) which bind to cAMP-responsive elements of gene promoters. By analyzing the transactivation activities and phosphorylations in vivo of deletion and point mutated chimeric fusion proteins of the placental CREB-327,...
Topics
- Amino Acid Sequence
- Binding Sites
- Cyclic AMP
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Kinases
- Serine
- Transcription Factors
- Transcription, Genetic
- Transcriptional Activation
- Tumor Cells, Cultured