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Article

Two cysteine residues in the DNA-binding domain of CREB control binding to CRE and CREB-mediated gene expression.

Journal of molecular biology - 2 Nov 2001

Goren I, Tavor E, Goldblum A, Honigman A

Abstract excerpt

The cAMP-responsive element-binding protein (CREB) has been implicated in the regulation of numerous physiological functions including those of several hypoxia-responding genes. All CREB transcription-regulated genes harbor the eight base-pair cAMP-responsive element (CRE) or the seven base-pair AP-1 sequence. Utilizing mutational analysis and biochemical assays, we found that reduction of two cysteine residues...

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Identifiers

PMID: 11697898
DOI: 10.1006/jmbi.2001.5064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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