A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.

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Article

A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.

The Journal of biological chemistry - 23 Dec 1994

Fiol C J, Williams J S, Chou C H, Wang Q M, Roach P J, Andrisani O M

Abstract excerpt

The cAMP-dependent protein kinase (PKA) phosphorylates CREB327/341 at a single serine residue, Ser119/133, respectively. Phosphorylation at this site creates the sequence motif SXXXS(P), a consensus site of the glycogen synthase kinase-3 (GSK-3) enzyme (Fiol, C.J., Mahrenholz, A.M., Wang, Y., Roeske, R.W., and Roach, P.J. (1987) J. Biol. Chem. 262, 14042-14048). We examined the phosphorylation of CREB at the...

Topics

Amino Acid Sequence
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cells, Cultured
Cyclic AMP
Cyclic AMP Response Element-Binding Protein
Gene Expression Regulation
Glycogen Synthase Kinase 3
Glycogen Synthase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

PC12 Cells

Peptide Mapping

Phosphorylation

Plasmids

Rabbits

Rats

Serine

Source

Open in PubMed

Identifiers

PMID: 7798217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7798217-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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