Article
Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding protein.
The Journal of biological chemistry - 2 Feb 2001
Fass D M, Craig J C, Impey S, Goodman R H
Abstract excerpt
Cyclic AMP-response element modulator alpha (CREMalpha) is a transcription factor that is highly related to cAMP-response element-binding protein (CREB) but represses cAMP-induced gene expression from simple artificial promoters containing a cAMP-response element (CRE). CREMalpha lacks two glutamine-rich Q regions that, in CREB, are thought to be necessary for transcriptional activation. Nevertheless, protein...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Amino Acid Substitution
- Binding Sites
- Cyclic AMP Response Element Modulator
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Phosphoenolpyruvate Carboxykinase (ATP)
- Repressor Proteins