Article
Characteristics of the cAMP response unit.
Metabolism: clinical and experimental - 1 Sept 1990
Montminy M R, Gonzalez G A, Yamamoto K K
Abstract excerpt
Cyclic AMP (cAMP) mediates the hormonal stimulation of numerous cellular processes by regulating the phosphorylation of critical target proteins. In this report, we review current work suggesting that cAMP regulates transcription of eukaryotic genes through the reversible phosphorylation of a target nuclear protein called CREB. As CREB is currently the only transcription factor that is regulated by a well-defined...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Cyclic AMP
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Eukaryotic Cells
- Humans
- Molecular Sequence Data
- Mutation