Article
Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon.
The Journal of biological chemistry - 26 Aug 2011
Suzuki Masato, Kiga Kotaro, Kersulyte Dangeruta, Cok Jaime, Hooper Catherine C, Mimuro Hitomi, Sanada Takahito, Suzuki Shiho, Oyama Masaaki, Kozuka-Hata Hiroko, Kamiya Shigeru, Zou Quan-Ming, Gilman Robert H, Berg Douglas E, Sasakawa Chihiro
Abstract excerpt
Population genetic analyses of bacterial genes whose products interact with host tissues can give new understanding of infection and disease processes. Here we show that strains of the genetically diverse gastric pathogen Helicobacter pylori from Amerindians from the remote Peruvian Amazon contain novel alleles of cagA, a major virulence gene, and reveal distinctive properties of their encoded CagA proteins. CagA...
Topics
- Alleles
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Antigens, Bacterial
- Bacterial Proteins
- Evolution, Molecular
- Female
- Gastric Mucosa
- Gerbillinae