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Article

A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island.

PLoS genetics - 19 Aug 2010

Olbermann Patrick, Josenhans Christine, Moodley Yoshan, Uhr Markus, Stamer Christiana, Vauterin Marc, Suerbaum Sebastian, Achtman Mark, Linz Bodo

Abstract excerpt

The Helicobacter pylori cag pathogenicity island (cagPAI) encodes a type IV secretion system. Humans infected with cagPAI-carrying H. pylori are at increased risk for sequelae such as gastric cancer. Housekeeping genes in H. pylori show considerable genetic diversity; but the diversity of virulence factors such as the cagPAI, which transports the bacterial oncogene CagA into host cells, has not been...

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Identifiers

PMID: 20808891
DOI: 10.1371/journal.pgen.1001069
PMCID: PMC2924317

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Source receipt: pubmed, retrieved 7 Sept 2026.

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