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Global Diversity of Helicobacter pylori Prophages Reveals Genetic Drivers of Virulence and Associations With Gastric Cancer.

Helicobacter - 1 Jan 2026

Li Zhenkai, Li Ying, Huang Shixuan, Shang Yanyan, Li Yuecong, Zhang Tiantian, Wei Xianhu, Xie Xinqiang, Wu Qingping, Zhao Xinyu

Abstract excerpt

BACKGROUND: Helicobacter pylori is a globally prevalent gastric pathogen, and chronic infection accounts for most gastric cancer (GC) cases worldwide. Major oncogenic determinants, including CagA, VacA, and the type IV secretion system, show marked geographic heterogeneity, yet the evolutionary forces shaping this uneven distribution remain unclear. Prophages can mediate horizontal gene transfer and modulate...

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PMID: 42363415
DOI: 10.1111/hel.70140

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GC

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