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Article

Polymorphisms influencing olanzapine metabolism and adverse effects in healthy subjects.

Human psychopharmacology - 1 May 2013

Cabaleiro Teresa, López-Rodríguez Rosario, Ochoa Dolores, Román Manuel, Novalbos Jesús, Abad-Santos Francisco

Abstract excerpt

OBJECTIVE: The pharmacokinetics of olanzapine and response to treatment could be affected by polymorphisms in genes coding for drug-metabolizing enzymes, transporters, or receptors. The aim of this study was to identify genetic markers predictive of pharmacokinetics, pharmacodynamics, and adverse effects of olanzapine. METHODS: Sixty-three healthy volunteers receiving a single 5-mg oral dose of olanzapine were...

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Source

Identifiers

PMID: 23559402
DOI: 10.1002/hup.2308

Genes

DRD2
GSTM3
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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