Article

Interindividual Variability in Olanzapine Steady-State Concentrations in Chinese: Exploring Single Nucleotide Polymorphisms of Metabolic Enzymes

2024-12-12

Abstract excerpt

<h4>Aims: </h4>: Olanzapine, a second-generation antipsychotic, can cause dose-adverse drug reactions. Its steady-state concentration can vary due to several factors. This study explores how physiological factors, smoking, inflammation, concomitant medications, and metabolic enzyme single nucleotide polymorphisms (SNPs) influence its metabolic levels, aiming to guide personalized dosing. <h4>Methods:</h4> This stu...

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Literature Corpus work: a64a96bc-3a77-5af1-a9b3-9b7c2c0e1f8e
DOI: 10.22541/au.173398701.15161653/v1

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