Article
Death-associated protein kinase 1 variation and Parkinson's disease.
European journal of neurology - 1 Aug 2011
Dachsel J C, Wider C, Vilariño-Güell C, Aasly J O, Rajput A, Rajput A H, Lynch T, Craig D, Krygowska-Wajs A, Jasinska-Myga B, Opala G, Barcikowska M, Czyzewski K, Wu R-M, Heckman M G, Uitti R J, Wszolek Z K, Farrer M J, Ross O A
Abstract excerpt
BACKGROUND AND PURPOSE: Mutations of the LRRK2 gene are now recognized as major risk factors for Parkinson's disease. The Lrrk2 protein is a member of the ROCO family, which also includes Lrrk1 and Dapk1. Functional genetic variants of the DAPK1 gene (rs4877365 and rs4878104) have been previously associated with Alzheimer's disease. METHODS: Herein, we assessed the role of DAPK1 variants (rs4877365 and rs4878104)...
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