Article
Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10).
Glia - 1 Nov 2011
Haj-Yasein Nadia Nabil, Jensen Vidar, Vindedal Gry Fluge, Gundersen Georg Andreas, Klungland Arne, Ottersen Ole Petter, Hvalby Oivind, Nagelhus Erlend Arnulf
Abstract excerpt
Mutations in the human Kir4.1 potassium channel gene (KCNJ10) are associated with epilepsy. Using a mouse model with glia-specific deletion of Kcnj10, we have explored the mechanistic underpinning of the epilepsy phenotype. The gene deletion was shown to delay K(+) clearance after synaptic activation in stratum radiatum of hippocampal slices. The activity-dependent changes in extracellular space volume did not...
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