Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination.

Abstract excerpt

To understand the cellular and in vivo functions of specific K(+) channels in glia, we have studied mice with a null mutation in the weakly inwardly rectifying K(+) channel subunit Kir4.1. Kir4.1-/- mice display marked motor impairment, and the cellular basis is hypomyelination in the spinal cord, accompanied by severe spongiform vacuolation, axonal swellings, and degeneration. Immunostaining in the spinal cord...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Demyelinating Diseases
• Share to Myelin Sheath