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Article

Deletion of the K(V)1.1 potassium channel causes epilepsy in mice.

Neuron - 1 Apr 1998

Smart S L, Lopantsev V, Zhang C L, Robbins C A, Wang H, Chiu S Y, Schwartzkroin P A, Messing A, Tempel B L

Abstract excerpt

Mice lacking the voltage-gated potassium channel alpha subunit, K(V)1.1, display frequent spontaneous seizures throughout adult life. In hippocampal slices from homozygous K(V)1.1 null animals, intrinsic passive properties of CA3 pyramidal cells are normal. However, antidromic action potentials a...

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Identifiers

PMID: 9581771
DOI: 10.1016/s0896-6273(00)81018-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9581771-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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