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Article

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.

Genes, brain, and behavior - 1 Apr 2014

Speca D J, Ogata G, Mandikian D, Bishop H I, Wiler S W, Eum K, Wenzel H Jürgen, Doisy E T, Matt L, Campi K L, Golub M S, Nerbonne J M, Hell J W, Trainor B C, Sack J T, Schwartzkroin P A, Trimmer J S

Abstract excerpt

The Kv2.1 delayed rectifier potassium channel exhibits high-level expression in both principal and inhibitory neurons throughout the central nervous system, including prominent expression in hippocampal neurons. Studies of in vitro preparations suggest that Kv2.1 is a key yet conditional regulator of intrinsic neuronal excitability, mediated by changes in Kv2.1 expression, localization and function via...

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Identifiers

PMID: 24494598
DOI: 10.1111/gbb.12120
PMCID: PMC4077602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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