Article
Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2008
Jacobs Stefan, Ruusuvuori Eva, Sipilä Sampsa T, Haapanen Aleksi, Damkier Helle H, Kurth Ingo, Hentschke Moritz, Schweizer Michaela, Rudhard York, Laatikainen Linda M, Tyynelä Jaana, Praetorius Jeppe, Voipio Juha, Hübner Christian A
Abstract excerpt
Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. Here we report that disrupting the Slc4a10 gene, which encodes the Na(+)-coupled Cl(-)-HCO(3)(-) exchanger Slc4a10 (NCBE), drastically reduces brain ventricle volume and protects against fatal epileptic seizures in mice. In choroid plexus epithelial cells, Slc4a10 localizes to the basolateral membrane. These...
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