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Article

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice.

Epilepsia - 1 Sept 2010

Inyushin Mikhail, Kucheryavykh Lilia Y, Kucheryavykh Yuriy V, Nichols Colin G, Buono Russell J, Ferraro Thomas N, Skatchkov Serguei N, Eaton Misty J

Abstract excerpt

PURPOSE: KCNJ10 encodes subunits of inward rectifying potassium (Kir) channel Kir4.1 found predominantly in glial cells within the brain. Genetic inactivation of these channels in glia impairs extracellular K(+) and glutamate clearance and produces a seizure phenotype. In both mice and humans, polymorphisms and mutations in the KCNJ10 gene have been associated with seizure susceptibility. The purpose of the...

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Identifiers

PMID: 20831751
DOI: 10.1111/j.1528-1167.2010.02592.x
PMCID: PMC3225007

Genes

KCNJ10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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