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Article

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

11 Sept 2018

Abstract excerpt

Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of KCNJ10, which encodes the inward-rectifying potassium channel KIR4.1, causes seizures and progressive neurological decline. We investigated Kir4.1 functions in oligodendrocytes (OLs) during development, adulthood and after WM injury. We observed that Kir4.1 channels...

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PMID: 30204081
DOI: 10.7554/elife.36428

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