Article

Bidirectional regulation of glial potassium buffering: glioprotection <i>versus</i> neuroprotection

2020-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Glia modulate neuronal excitability and seizure sensitivity by maintaining potassium and water homeostasis. A SIK3-regulated gene expression program controls the glial capacity to buffer K + and water, however upstream regulatory mechanisms are unknown. Here we identify an octopaminergic circuit linking neuronal activity to glial ion and water buffering. Under basal conditions, octopamine funct...

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Literature Corpus work: 4ae44d65-f392-590b-b7cf-78528f624c4b
DOI: 10.1101/2020.09.17.301424

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