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Article

Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury.

American journal of physiology. Heart and circulatory physiology - 15 Jan 2013

Talukder M A Hassan, Elnakish Mohammad T, Yang Fuchun, Nishijima Yoshinori, Alhaj Mazin A, Velayutham Murugesan, Hassanain Hamdy H, Zweier Jay L

Abstract excerpt

The GTP-binding protein Rac regulates diverse cellular functions including activation of NADPH oxidase, a major source of superoxide production (O(2)(·-)). Rac1-mediated NADPH oxidase activation is increased after myocardial infarction (MI) and heart failure both in animals and humans; however, the impact of increased myocardial Rac on impending ischemia-reperfusion (I/R) is unknown. A novel transgenic mouse...

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Identifiers

PMID: 23161879
DOI: 10.1152/ajpheart.00367.2012
PMCID: PMC3543663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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