Article
Role of direct RhoA-phospholipase D1 interaction in mediating adenosine-induced protection from cardiac ischemia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2004
Mozzicato Susan, Joshi Bhalchandra V, Jacobson Kenneth A, Liang Bruce T
Abstract excerpt
Activation of adenosine A1 or A3 receptors protects heart cells from ischemia-induced injury. The A3 receptor signals via RhoA and phospholipase D (PLD) to induce cardioprotection. The objective of the study was to investigate how RhoA activates PLD to achieve the anti-ischemic effect of adenosine A3 receptors. In an established cardiac myocyte model of preconditioning using the cultured chick embryo heart cells,...
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