Article
Activated T cells from umbilical cord blood armed with anti-CD3 × anti-CD20 bispecific antibody mediate specific cytotoxicity against CD20+ targets with minimal allogeneic reactivity: a strategy for providing antitumor effects after cord blood transplants.
Transfusion - 1 Jan 2012
Thakur Archana, Sorenson Carly, Norkina Oxana, Schalk Dana, Ratanatharathorn Voravit, Lum Lawrence G
Abstract excerpt
BACKGROUND: In this study, we asked whether anti-CD3-activated T cells (ATCs) from cord blood (CB) could be expanded and targeted to solid tumors or hematologic malignancies for infusions after unrelated CB stem cell transplant and whether cord blood ATCs (CBATCs) could reduce alloresponsiveness. STUDY DESIGN AND METHODS: CB mononuclear cells (MNCs) were activated with anti-CD3 (20 ng/mL) and expanded for 14 days...
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