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Efficient generation of CAR NK cells from human umbilical cord blood CD34 <sup>+</sup> stem and progenitors for democratizing affordable immunotherapy

2024-07-30

Abstract excerpt

Chimeric antigen receptor (CAR) natural killer cells (CAR NK) cells, leveraging safety and not requiring HLA match in adoptive infusion, have emerged as promising alternative cells to CAR-T cells for immunotherapies. High and multiple doses of CAR NK cell infusions are essential to maintain therapeutic efficacy in clinical trials. This requires efficient methods for generating large-scale CAR NK cells and signific...

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Literature Corpus work
b7f24669-2abf-5d65-8e97-df64b92fe7ce
DOI
10.1101/2024.07.30.605741
Open publication

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Efficient generation of CAR NK cells from human umbilical cord blood CD34 <sup>+</sup> stem and progenitors for democratizing affordable immunotherapyDOI 10.1101/2024.07.30.605741
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