Article
The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations.
Cancer - 15 Nov 2010
Norquist Barbara M, Garcia Rochelle L, Allison Kimberly H, Jokinen Chris H, Kernochan Lauren E, Pizzi Catherine C, Barrow Bethany J, Goff Barbara A, Swisher Elizabeth M
Abstract excerpt
BACKGROUND: BRCA1 or BRCA2 (BRCA1/2)-mutated ovarian carcinomas may originate in the fallopian tube. The authors of this report investigated alterations in BRCA1/2 tubal epithelium to define the molecular pathogenesis of these carcinomas. METHODS: Tubal epithelium was evaluated from 31 BRCA1/2 mutation carriers with gynecologic carcinomas (BRCA CA), 89 mutation carriers who underwent risk-reducing...
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