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Article

The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells.

Investigative ophthalmology & visual science - 29 Aug 2011

Lau Ling-Ing, Chiou Shih-Hwa, Liu Catherine Jui-Ling, Yen May-Yung, Wei Yau-Huei

Abstract excerpt

PURPOSE: Genetic variation in complement factor H (CFH) has been implicated as a major risk factor for age-related macular degeneration (AMD). The reduction in CFH amount or its complement-modulating activity may lead to inadequate control of complement-driven inflammation at the outer retina. We explored the effect of photo-oxidative stress and inflammatory cytokine on the expression of CFH in retinal pigment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21743006
DOI: 10.1167/iovs.11-7815

Genes

CFH
RPE

Provenance

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The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells.PMID 21743006Read ↗

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CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB PathwaySemantic proximity Read ↗

Interlink between Inflammation and Oxidative Stress in Age-Related Macular Degeneration: Role of Complement Factor HSemantic proximity Read ↗

<i>CFH</i> loss in human RPE cells leads to inflammation and complement system dysregulation <i>via</i> the NF-κB pathwaySemantic proximity Read ↗

CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complexSemantic proximity Read ↗

Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3.Semantic proximity Read ↗

Interleukin 27 Induces the Expression of Complement Factor H (CFH) in the RetinaSemantic proximity Read ↗

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