Article
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress.
Nature - 5 Oct 2011
Weismann David, Hartvigsen Karsten, Lauer Nadine, Bennett Keiryn L, Scholl Hendrik P N, Charbel Issa Peter, Cano Marisol, Brandstätter Hubert, Tsimikas Sotirios, Skerka Christine, Superti-Furga Giulio, Handa James T, Zipfel Peter F, Witztum Joseph L, Binder Christoph J
Abstract excerpt
Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory diseases, including age-related macular degeneration (AMD). AMD is the leading cause of blindness in Western societies, but its aetiology remains largely unknown. Malondialdehyde (MDA) is a common lipid peroxidation product that accumulates in many pathophysiological processes, including AMD. Here we identify complement...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.