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Article

Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration.

Cells - 30 Jun 2022

Ebeling Mara C, Fisher Cody R, Kapphahn Rebecca J, Stahl Madilyn R, Shen Shichen, Qu Jun, Montezuma Sandra R, Ferrington Deborah A

Abstract excerpt

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is characterized by the death of retinal pigment epithelium (RPE) and photoreceptors. One of the risk factors associated with developing AMD is the single nucleotide polymorphism (SNP) found within the gene encoding complement factor H (CFH). Part of the innate immune system, CFH inhibits alternative complement pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35805159
DOI: 10.3390/cells11132075
PMCID: PMC9265516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration.PMID 35805159Read ↗

CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulation.Semantic proximity Read ↗

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB PathwaySemantic proximity Read ↗

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Exogenous CFH Modulates Levels of Pro-Inflammatory Mediators to Prevent Oxidative Damage of Retinal Pigment Epithelial Cells with the At-Risk CFH Y402H VariantSemantic proximity Read ↗

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular DegenerationSemantic proximity Read ↗

Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variantsSemantic proximity Read ↗

The Noncanonical Role of Complement Factor H in Retinal Pigment Epithelium (RPE) Cells and Implications for Age-Related Macular Degeneration (AMD).Semantic proximity Read ↗

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