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Article

Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3.

The Journal of biological chemistry - 3 Aug 2007

Wu Zhihao, Lauer Thomas W, Sick Anna, Hackett Sean F, Campochiaro Peter A

Abstract excerpt

Age-related macular degeneration (AMD), the leading cause of severe vision loss in the elderly, is a complex disease that results from genetic modifications that increase susceptibility to environmental exposures. Smoking, a major source of oxidative stress, increases the incidence and severity o...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O3

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Share to Interferon-gamma

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Share to Pigment Epithelium of Eye

Source

Identifiers

PMID: 17558024
DOI: 10.1074/jbc.M702321200

Genes

CFH
FOXO3
STAT1
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17558024-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3.PMID 17558024Read ↗

Protein Acetylation in Age-Related Macular Degeneration: Mechanisms, Roles, and Therapeutic PerspectivesSemantic proximity Read ↗

The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells.Semantic proximity Read ↗

Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort.Semantic proximity Read ↗

Exogenous CFH Modulates Levels of Pro-Inflammatory Mediators to Prevent Oxidative Damage of Retinal Pigment Epithelial Cells with the At-Risk CFH Y402H VariantSemantic proximity Read ↗

Interleukin 27 Induces the Expression of Complement Factor H (CFH) in the RetinaSemantic proximity Read ↗

Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration.Semantic proximity Read ↗

Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration.Semantic proximity Read ↗

Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment EpitheliumSemantic proximity Read ↗

The Complement Factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium.Semantic proximity Read ↗

CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complexSemantic proximity Read ↗

Metformin Attenuates ROS via FOXO3 Activation in Immune Cells.Semantic proximity Read ↗

FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.Semantic proximity Read ↗

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