Article
Transforming growth factor β 869C/T and interleukin 6 -174G/C polymorphisms relate to the severity and progression of bone-erosive damage detected by ultrasound in rheumatoid arthritis.
Arthritis research & therapy - 8 Jul 2011
Ceccarelli Fulvia, Perricone Carlo, Fabris Martina, Alessandri Cristiano, Iagnocco Annamaria, Fabro Cinzia, Pontarini Elena, De Vita Salvatore, Valesini Guido
Abstract excerpt
INTRODUCTION: Single nucleotide polymorphisms (SNPs) of transforming growth factor β (TGF-β) and IL-6 genes (respectively, 869C/T and -174G/C) have been associated with radiographic severity of bone-erosive damage in patients with rheumatoid arthritis (RA). Musculoskeletal ultrasound (US) is more sensitive than radiography in detecting bone erosion. We analyzed the association between TGF-β 869C/T and IL-6...
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