Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transforming growth factor-beta1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis.

Rheumatology (Oxford, England) - 1 Feb 2009

Panoulas V F, Douglas K M J, Smith J P, Stavropoulos-Kalinoglou A, Metsios G S, Nightingale P, Kitas G D

Abstract excerpt

OBJECTIVES: Part of the deleterious effects of systemic inflammation on the cardiovascular system of patients with RA may be exerted via increased propensity to hypertension. IL-6 and TGF-beta1 are important regulators of the inflammatory response. In some, but not all, studies, IL6 -174G/C (rs1800795) and TGFB1 869T/C (rs1982073) gene polymorphisms have been associated with hypertension in the general...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid
Share to Case-Control Studies
Share to Gene Frequency
Share to Hypertension
Share to Interleukin-6
Share to Logistic Models
Share to Risk
Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 19106168
DOI: 10.1093/rheumatology/ken443

Genes

TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transforming growth factor-beta1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis.PMID 19106168Read ↗

TGF-β1 +869C/T polymorphism increases susceptibility to rheumatoid arthritis in North Indian population.Semantic proximity Read ↗

Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study.Semantic proximity Read ↗

TGFB1 (rs1800470 and rs1800469) variants are independently associated with disease activity and autoantibodies in rheumatoid arthritis patients.Semantic proximity Read ↗

TGF-β1 +869T/C (rs1982073) gene polymorphism and susceptibility to rheumatoid arthritis: Updated systematic review and meta-analysis.Semantic proximity Read ↗

TGFB1 +869 T > C (rs1800470) variant is independently associated with susceptibility, laboratory activity, and TGF-β1 in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking.Semantic proximity Read ↗

Study of transforming growth factor beta 1 gene +869T/C polymorphism in Egyptian rheumatoid arthritis patients and its relation to disease activity.Semantic proximity Read ↗

Transforming growth factor beta1 gene polymorphism in rheumatoid arthritis.Semantic proximity Read ↗

Association of TGF-β1 +869C/T promoter polymorphism with susceptibility to autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals.Semantic proximity Read ↗

Interaction between TGF-β1 (869C/T) polymorphism and biochemical risk factor for prediction of disease progression in rheumatoid arthritis.Semantic proximity Read ↗

Association of transforming growth factor-β1 T869C, G915C, and C509T gene polymorphisms with rheumatoid arthritis risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.