NFKB1 promoter -94 insertion/deletion ATTG polymorphism (rs28362491) is associated with severity and disease progression of rheumatoid arthritis through interleukin-6 levels modulation in Egyptian patients.

doi:10.1007/s10067-021-05584-z

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NFKB1 promoter -94 insertion/deletion ATTG polymorphism (rs28362491) is associated with severity and disease progression of rheumatoid arthritis through interleukin-6 levels modulation in Egyptian patients.

Clinical rheumatology - 1 Jul 2021

Elkhawaga Samy Y, Gomaa Maher H, Elsayed Mohsen M, Ebeed Ahmed A

Abstract excerpt

OBJECTIVE: Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder, which can cause progressive and functional disability. Previous data suggests that some inflammatory cytokines are dysregulated in patients with RA. Polymorphisms in the NFKB1 gene were studied in different populations with RA. Specific studies showed that the NFKB1 promoter -94ins/delATTG (rs28362491) polymorphism appears to be...

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PMID: 33459954
DOI: 10.1007/s10067-021-05584-z

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NFKB1

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