Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis.

doi:10.1186/s13075-015-0737-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis.

Arthritis research & therapy - 4 Sept 2015

Lopez-Lasanta Maria, Julià Antonio, Maymó Joan, Fernández-Gutierrez Benjamín, Ureña-Garnica Inmaculada, Blanco Francisco J, Cañete Juan D, Alperi-López Mercedes, Olivè Alex, Corominas Héctor, Tornero Jesus, Erra Alba, Almirall Miriam, Palau Nuria, Ortiz Ana, Avila Gabriela, Rodriguez-Rodriguez Luis, Alonso Arnald, Tortosa Raül, Gonzalez-Alvaro Isidoro, Marsal Sara

Abstract excerpt

INTRODUCTION: Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. This study was performed to investigate the association between the genetic variation at IL6R gene and the severity of joint damage in RA. METHODS: IL6R gene tagging SNPs (n = 5) were genotyped in a discovery...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Joints

Share to Linear Models

Share to Linkage Disequilibrium

Share to Meta-Analysis as Topic

Share to Receptors, Interleukin-6

Share to Spain

Source

Open in PubMed Open full text

Identifiers

PMID: 26336855
DOI: 10.1186/s13075-015-0737-8
PMCID: PMC4560075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis.PMID 26336855Read ↗

Assessment of interleukin 6 gene polymorphisms with rheumatoid arthritis.Semantic proximity Read ↗

Interleukin 6 Receptor (IL6-R) Gene Polymorphisms Underlie Susceptibility to Rheumatoid Arthritis.Semantic proximity Read ↗

A gain of function polymorphism in the interleukin 6 receptor influences RA susceptibility.Semantic proximity Read ↗

Relationship between polymorphisms in -572G/C interleukin 6 promoter gene polymorphisms (rs1800796) and risk of rheumatoid arthritis: A meta-analysis.Semantic proximity Read ↗

Genetic and expression deregulation of immunoregulatory genes in rheumatoid arthritis.Semantic proximity Read ↗

Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes.Semantic proximity Read ↗

Interleukin 6 gene polymorphism is associated with protein serum level and disease activity in Polish patients with rheumatoid arthritis.Semantic proximity Read ↗

Association between IL-6, miRNA-146a, MALAT1 genetic polymorphisms and risk of rheumatoid arthritis.Semantic proximity Read ↗

Association between interleukin-6 gene polymorphisms and rheumatoid arthritis in Chinese Han population: a case-control study and a meta-analysis.Semantic proximity Read ↗

The interleukin 6 receptor alpha gene polymorphisms are associated with clinical manifestations of systemic lupus erythematosus in Koreans.Semantic proximity Read ↗

Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis.Semantic proximity Read ↗

Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.