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Article

Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women.

Nutrition and cancer - 1 Jan 2011

Curtin Karen, Samowitz Wade S, Ulrich Cornelia M, Wolff Roger K, Herrick Jennifer S, Caan Bette J, Slattery Martha L

Abstract excerpt

In an investigation of rectal tumors characterized by CpG island methylator phenotype (CIMP), KRAS2 mutation, and TP53 mutation, we examined associations with dietary and supplemental folate, riboflavin, vitamins B(6) and B(12), and methionine, nutrients involved in folate-mediated 1-carbon metabolism. We also examined folate intake and common MTHFR polymorphisms in relation to CIMP. Data from a population-based...

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Identifiers

PMID: 21462086
DOI: 10.1080/01635581.2011.535965
PMCID: PMC3127576

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MTHFR

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